| それ以前 |
12. Maiko Moriyama, Takahiro Sato, Hromasa Inoue, Satoru Fukuyama, Hitoshi Teranishi, Kenji Kangawa, Tatsuhiko Kano, Akihiko Yoshimura and Masayasu Kojima. The neuropeptide neuromedin U prometes inflammation by direct activation of mast cells. Journal of Experimental Medicine 202(2):217-24 (2005)
1. Yabuki A, Ojima T, Kojima M, Nishi Y, Mifune H, Matsumoto M, Kamimura R, Masuyama T, Suzuki S. Characterization and species differences in gastric ghrelin cells from mice, rats and hamsters. J Anat 2004;205(3):239-46.
2. Togo T, Hasegawa K, Miura S, Hosojima H, Kojima K, Shoji M, Kase A, Uchikado H, Iseki E, Kosaka K. Serum ghrelin concentrations in patients receiving olanzapine or risperidone. Psychopharmacology (Berl) 2004;172(2):230-2.
3. Tanaka M, Nakahara T, Kojima S, Nakano T, Muranaga T, Nagai N, Ueno H, Nakazato M, Nozoe S, Naruo T. Effect of nutritional rehabilitation on circulating ghrelin and growth hormone levels in patients with anorexia nervosa. Regul Pept 2004;122(3):163-8.
4. Sugino T, Hasegawa Y, Kurose Y, Kojima M, Kangawa K, Terashima Y. Effects of ghrelin on food intake and neuroendocrine function in sheep. Anim Reprod Sci 2004;82-83:183-94.
5. Shibata K, Hosoda H, Kojima M, Kangawa K, Makino Y, Makino I, Kawarabayashi T, Futagami K, Gomita Y. Regulation of ghrelin secretion during pregnancy and lactation in the rat: possible involvement of hypothalamus. Peptides 2004;25(2):279-87.
6. Nakahara K, Hanada R, Murakami N, Teranishi H, Ohgusu H, Fukushima N, Moriyama M, Ida T, Kangawa K, Kojima M. The gut-brain peptide neuromedin U is involved in the mammalian circadian oscillator system. Biochem Biophys Res Commun 2004;318(1):156-61.
7. Nakahara K, Kojima M, Hanada R, Egi Y, Ida T, Miyazato M, Kangawa K, Murakami N. Neuromedin U is involved in nociceptive reflexes and adaptation to environmental stimuli in mice. Biochem Biophys Res Commun 2004;323(2):615-20.
8. Moriyama M, Furue H, Katafuchi T, Teranishi H, Sato T, Kano T, Kojima M, Yoshimura M. Presynaptic modulation by neuromedin U of sensory synaptic transmission in rat spinal dorsal horn neurones. J Physiol 2004;559(Pt 3):707-13.
9. Miura H, Tsuchiya N, Sasaki I, Kikuchi M, Kojima M, Kangawa K, Hasegawa Y, Ohnami Y. Changes in plasma ghrelin and growth hormone concentrations in mature Holstein cows and three-month-old calves. J Anim Sci 2004;82(5):1329-33.
10. Kojima M, Kangawa K. [Structure of ghrelin]. Nippon Rinsho 2004;62 Suppl 9:324-7.
11. Kojima M, Hosoda H, Kangawa K. Clinical endocrinology and metabolism. Ghrelin, a novel growth-hormone-releasing and appetite-stimulating peptide from stomach. Best Pract Res Clin Endocrinol Metab 2004;18(4):517-30.
12. Kangawa K, Kojima M, Hosoda H. [Discovery of ghrelin and its physiological significance]. Nippon Rinsho 2004;62 Suppl 9:317-23.
13. Kanamoto N, Akamizu T, Tagami T, Hataya Y, Moriyama K, Takaya K, Hosoda H, Kojima M, Kangawa K, Nakao K. Genomic structure and characterization of the 5'-flanking region of the human ghrelin gene. Endocrinology 2004;145(9):4144-53.
14. Kaiya H, Sakata I, Kojima M, Hosoda H, Sakai T, Kangawa K. Structural determination and histochemical localization of ghrelin in the red-eared slider turtle, Trachemys scripta elegans. Gen Comp Endocrinol 2004;138(1):50-7.
15. Hanada R, Teranishi H, Pearson JT, Kurokawa M, Hosoda H, Fukushima N, Fukue Y, Serino R, Fujihara H, Ueta Y, Ikawa M, Okabe M, Murakami N, Shirai M, Yoshimatsu H, Kangawa K, Kojima M. Neuromedin U has a novel anorexigenic effect independent of the leptin signaling pathway. Nat Med 2004;10(10):1067-73.
1. Tanaka K, Minoura H, Isobe T, Yonaha H, Kawato H, Wang DF, Yoshida T, Kojima M, Kangawa K, Toyoda N. Ghrelin is involved in the decidualization of human endometrial stromal cells. J Clin Endocrinol Metab 2003;88(5):2335-40.
2. Sugino T, Yamaura J, Yamagishi M, Kurose Y, Kojima M, Kangawa K, Hasegawa Y, Terashima Y. Involvement of cholinergic neurons in the regulation of the ghrelin secretory response to feeding in sheep. Biochem Biophys Res Commun 2003;304(2):308-12.
3. Shimizu Y, Nagaya N, Isobe T, Imazu M, Okumura H, Hosoda H, Kojima M, Kangawa K, Kohno N. Increased plasma ghrelin level in lung cancer cachexia. Clin Cancer Res 2003;9(2):774-8.
4. Okimura Y, Ukai K, Hosoda H, Murata M, Iguchi G, Iida K, Kaji H, Kojima M, Kangawa K, Chihara K. The role of circulating ghrelin in growth hormone (GH) secretion in freely moving male rats. Life Sci 2003;72(22):2517-24.
5. Nakahara K, Hayashida T, Nakazato M, Kojima M, Hosoda H, Kangawa K, Murakami N. Effect of chronic treatments with ghrelin on milk secretion in lactating rats. Biochem Biophys Res Commun 2003;303(3):751-5.
6. Kaiya H, Kojima M, Hosoda H, Riley LG, Hirano T, Grau EG, Kangawa K. Amidated fish ghrelin: purification, cDNA cloning in the Japanese eel and its biological activity. J Endocrinol 2003;176(3):415-23.
7. Kaiya H, Kojima M, Hosoda H, Riley LG, Hirano T, Grau EG, Kangawa K. Identification of tilapia ghrelin and its effects on growth hormone and prolactin release in the tilapia, Oreochromis mossambicus. Comp Biochem Physiol B Biochem Mol Biol 2003;135(3):421-9.
8. Kaiya H, Kojima M, Hosoda H, Moriyama S, Takahashi A, Kawauchi H, Kangawa K. Peptide purification, complementary deoxyribonucleic acid (DNA) and genomic DNA cloning, and functional characterization of ghrelin in rainbow trout. Endocrinology 2003;144(12):5215-26.
9. Hosoda H, Kojima M, Mizushima T, Shimizu S, Kangawa K. Structural divergence of human ghrelin. Identification of multiple ghrelin-derived molecules produced by post-translational processing. J Biol Chem 2003;278(1):64-70.
10. Horio T, Tokudome T, Maki T, Yoshihara F, Suga S, Nishikimi T, Kojima M, Kawano Y, Kangawa K. Gene expression, secretion, and autocrine action of C-type natriuretic peptide in cultured adult rat cardiac fibroblasts. Endocrinology 2003;144(6):2279-84.
11. Hashizume T, Horiuchi M, Tate N, Nonaka S, Mikami U, Kojima M. Effects of Ghrelin on growth hormone secretion from cultured adenohypophysial cells in pigs. Domest Anim Endocrinol 2003;24(3):209-18.
12. Hashizume T, Horiuchi M, Tate N, Nonaka S, Kojima M, Hosoda H, Kangawa K. Effects of ghrelin on growth hormone secretion from cultured adenohypophysial cells in cattle. Endocr J 2003;50(3):289-95.
13. Enomoto M, Nagaya N, Uematsu M, Okumura H, Nakagawa E, Ono F, Hosoda H, Oya H, Kojima M, Kanmatsuse K, Kangawa K. Cardiovascular and hormonal effects of subcutaneous administration of ghrelin, a novel growth hormone-releasing peptide, in healthy humans. Clin Sci (Lond) 2003;105(4):431-5.
15. Choi K, Roh SG, Hong YH, Shrestha YB, Hishikawa D, Chen C, Kojima M, Kangawa K, Sasaki S. The role of ghrelin and growth hormone secretagogues receptor on rat adipogenesis. Endocrinology 2003;144(3):754-9.
1. Yoshimoto A, Mori K, Sugawara A, Mukoyama M, Yahata K, Suganami T, Takaya K, Hosoda H, Kojima M, Kangawa K, Nakao K. Plasma ghrelin and desacyl ghrelin concentrations in renal failure. J Am Soc Nephrol 2002;13(11):2748-52.
2. Yoshihara F, Kojima M, Hosoda H, Nakazato M, Kangawa K. Ghrelin: a novel peptide for growth hormone release and feeding regulation. Curr Opin Clin Nutr Metab Care 2002;5(4):391-5.
3. Sugino T, Hasegawa Y, Kikkawa Y, Yamaura J, Yamagishi M, Kurose Y, Kojima M, Kangawa K, Terashima Y. A transient ghrelin surge occurs just before feeding in a scheduled meal-fed sheep. Biochem Biophys Res Commun 2002;295(2):255-60.
4. Sugino T, Yamaura J, Yamagishi M, Ogura A, Hayashi R, Kurose Y, Kojima M, Kangawa K, Hasegawa Y, Terashima Y. A transient surge of ghrelin secretion before feeding is modified by different feeding regimens in sheep. Biochem Biophys Res Commun 2002;298(5):785-8.
5. Norrelund H, Hansen TK, Orskov H, Hosoda H, Kojima M, Kangawa K, Weeke J, Moller N, Christiansen JS, Jorgensen JO. Ghrelin immunoreactivity in human plasma is suppressed by somatostatin. Clin Endocrinol (Oxf) 2002;57(4):539-46.
6. Nakagawa E, Nagaya N, Okumura H, Enomoto M, Oya H, Ono F, Hosoda H, Kojima M, Kangawa K. Hyperglycaemia suppresses the secretion of ghrelin, a novel growth-hormone-releasing peptide: responses to the intravenous and oral administration of glucose. Clin Sci (Lond) 2002;103(3):325-8.
7. Murata M, Okimura Y, Iida K, Matsumoto M, Sowa H, Kaji H, Kojima M, Kangawa K, Chihara K. Ghrelin modulates the downstream molecules of insulin signaling in hepatoma cells. J Biol Chem 2002;277(7):5667-74.
8. Murakami N, Hayashida T, Kuroiwa T, Nakahara K, Ida T, Mondal MS, Nakazato M, Kojima M, Kangawa K. Role for central ghrelin in food intake and secretion profile of stomach ghrelin in rats. J Endocrinol 2002;174(2):283-8.
9. Makino Y, Hosoda H, Shibata K, Makino I, Kojima M, Kangawa K, Kawarabayashi T. Alteration of plasma ghrelin levels associated with the blood pressure in pregnancy. Hypertension 2002;39(3):781-4.
10. Lu S, Guan JL, Wang QP, Uehara K, Yamada S, Goto N, Date Y, Nakazato M, Kojima M, Kangawa K, Shioda S. Immunocytochemical observation of ghrelin-containing neurons in the rat arcuate nucleus. Neurosci Lett 2002;321(3):157-60.
11. Lee HM, Wang G, Englander EW, Kojima M, Greeley GH, Jr. Ghrelin, a new gastrointestinal endocrine peptide that stimulates insulin secretion: enteric distribution, ontogeny, influence of endocrine, and dietary manipulations. Endocrinology 2002;143(1):185-90.
12. Kojima M, Kangawa K. Ghrelin, an orexigenic signaling molecule from the gastrointestinal tract. Curr Opin Pharmacol 2002;2(6):665-8.
13. Kaiya H, Van Der Geyten S, Kojima M, Hosoda H, Kitajima Y, Matsumoto M, Geelissen S, Darras VM, Kangawa K. Chicken ghrelin: purification, cDNA cloning, and biological activity. Endocrinology 2002;143(9):3454-63.
14. Iwakura H, Hosoda K, Doi R, Komoto I, Nishimura H, Son C, Fujikura J, Tomita T, Takaya K, Ogawa Y, Hayashi T, Inoue G, Akamizu T, Hosoda H, Kojima M, Kangawa K, Imamura M, Nakao K. Ghrelin expression in islet cell tumors: augmented expression of ghrelin in a case of glucagonoma with multiple endocrine neoplasm type I. J Clin Endocrinol Metab 2002;87(11):4885-8.
15. Ikezaki A, Hosoda H, Ito K, Iwama S, Miura N, Matsuoka H, Kondo C, Kojima M, Kangawa K, Sugihara S. Fasting plasma ghrelin levels are negatively correlated with insulin resistance and PAI-1, but not with leptin, in obese children and adolescents. Diabetes 2002;51(12):3408-11.
16. Hosoda H, Kojima M, Kangawa K. Ghrelin and the regulation of food intake and energy balance. Mol Interv 2002;2(8):494-503.
17. Hayashida T, Nakahara K, Mondal MS, Date Y, Nakazato M, Kojima M, Kangawa K, Murakami N. Ghrelin in neonatal rats: distribution in stomach and its possible role. J Endocrinol 2002;173(2):239-45.
18. Hansen TK, Dall R, Hosoda H, Kojima M, Kangawa K, Christiansen JS, Jorgensen JO. Weight loss increases circulating levels of ghrelin in human obesity. Clin Endocrinol (Oxf) 2002;56(2):203-6.
19. Galas L, Chartrel N, Kojima M, Kangawa K, Vaudry H. Immunohistochemical localization and biochemical characterization of ghrelin in the brain and stomach of the frog Rana esculenta. J Comp Neurol 2002;450(1):34-44.
20. Date Y, Nakazato M, Hashiguchi S, Dezaki K, Mondal MS, Hosoda H, Kojima M, Kangawa K, Arima T, Matsuo H, Yada T, Matsukura S. Ghrelin is present in pancreatic alpha-cells of humans and rats and stimulates insulin secretion. Diabetes 2002;51(1):124-9.
22. Ariyasu H, Takaya K, Hosoda H, Iwakura H, Ebihara K, Mori K, Ogawa Y, Hosoda K, Akamizu T, Kojima M, Kangawa K, Nakao K. Delayed short-term secretory regulation of ghrelin in obese animals: evidenced by a specific RIA for the active form of ghrelin. Endocrinology 2002;143(9):3341-50.
1. Toshinai K, Mondal MS, Nakazato M, Date Y, Murakami N, Kojima M, Kangawa K, Matsukura S. Upregulation of Ghrelin expression in the stomach upon fasting, insulin-induced hypoglycemia, and leptin administration. Biochem Biophys Res Commun 2001;281(5):1220-5.
2. Shintani M, Ogawa Y, Ebihara K, Aizawa-Abe M, Miyanaga F, Takaya K, Hayashi T, Inoue G, Hosoda K, Kojima M, Kangawa K, Nakao K. Ghrelin, an endogenous growth hormone secretagogue, is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/Y1 receptor pathway. Diabetes 2001;50(2):227-32.
3. Nakazato M, Murakami N, Date Y, Kojima M, Matsuo H, Kangawa K, Matsukura S. A role for ghrelin in the central regulation of feeding. Nature 2001;409(6817):194-8.
4. Nagaya N, Kojima M, Uematsu M, Yamagishi M, Hosoda H, Oya H, Hayashi Y, Kangawa K. Hemodynamic and hormonal effects of human ghrelin in healthy volunteers. Am J Physiol Regul Integr Comp Physiol 2001;280(5):R1483-7.
5. Nagaya N, Uematsu M, Kojima M, Ikeda Y, Yoshihara F, Shimizu W, Hosoda H, Hirota Y, Ishida H, Mori H, Kangawa K. Chronic administration of ghrelin improves left ventricular dysfunction and attenuates development of cardiac cachexia in rats with heart failure. Circulation 2001;104(12):1430-5.
6. Nagaya N, Uematsu M, Kojima M, Date Y, Nakazato M, Okumura H, Hosoda H, Shimizu W, Yamagishi M, Oya H, Koh H, Yutani C, Kangawa K. Elevated circulating level of ghrelin in cachexia associated with chronic heart failure: relationships between ghrelin and anabolic/catabolic factors. Circulation 2001;104(17):2034-8.
7. Nagaya N, Miyatake K, Uematsu M, Oya H, Shimizu W, Hosoda H, Kojima M, Nakanishi N, Mori H, Kangawa K. Hemodynamic, renal, and hormonal effects of ghrelin infusion in patients with chronic heart failure. J Clin Endocrinol Metab 2001;86(12):5854-9.
8. Matsumoto M, Kitajima Y, Iwanami T, Hayashi Y, Tanaka S, Minamitake Y, Hosoda H, Kojima M, Matsuo H, Kangawa K. Structural similarity of ghrelin derivatives to peptidyl growth hormone secretagogues. Biochem Biophys Res Commun 2001;284(3):655-9.
9. Matsumoto M, Hosoda H, Kitajima Y, Morozumi N, Minamitake Y, Tanaka S, Matsuo H, Kojima M, Hayashi Y, Kangawa K. Structure-activity relationship of ghrelin: pharmacological study of ghrelin peptides. Biochem Biophys Res Commun 2001;287(1):142-6.
10. Korbonits M, Bustin SA, Kojima M, Jordan S, Adams EF, Lowe DG, Kangawa K, Grossman AB. The expression of the growth hormone secretagogue receptor ligand ghrelin in normal and abnormal human pituitary and other neuroendocrine tumors. J Clin Endocrinol Metab 2001;86(2):881-7.
11. Korbonits M, Kojima M, Kangawa K, Grossman AB. Presence of ghrelin in normal and adenomatous human pituitary. Endocrine 2001;14(1):101-4.
12. Kojima M, Hosoda H, Matsuo H, Kangawa K. Ghrelin: discovery of the natural endogenous ligand for the growth hormone secretagogue receptor. Trends Endocrinol Metab 2001;12(3):118-22.
13. Kojima M, Kangawa K. [Ghrelin: a novel growth-hormone releasing peptide]. Nippon Rinsho 2001;59(7):1400-7.
14. Kojima M, Hosoda H, Kangawa K. Purification and distribution of ghrelin: the natural endogenous ligand for the growth hormone secretagogue receptor. Horm Res 2001;56 Suppl 1:93-7.
15. Kanamoto N, Akamizu T, Hosoda H, Hataya Y, Ariyasu H, Takaya K, Hosoda K, Saijo M, Moriyama K, Shimatsu A, Kojima M, Kangawa K, Nakao K. Substantial production of ghrelin by a human medullary thyroid carcinoma cell line. J Clin Endocrinol Metab 2001;86(10):4984-90.
16. Kallio J, Pesonen U, Karvonen MK, Kojima M, Hosoda H, Kangawa K, Koulu M. Enhanced exercise-induced GH secretion in subjects with Pro7 substitution in the prepro-NPY. J Clin Endocrinol Metab 2001;86(11):5348-52.
17. Kaiya H, Kojima M, Hosoda H, Koda A, Yamamoto K, Kitajima Y, Matsumoto M, Minamitake Y, Kikuyama S, Kangawa K. Bullfrog ghrelin is modified by n-octanoic acid at its third threonine residue. J Biol Chem 2001;276(44):40441-8.
18. Hayashida T, Murakami K, Mogi K, Nishihara M, Nakazato M, Mondal MS, Horii Y, Kojima M, Kangawa K, Murakami N. Ghrelin in domestic animals: distribution in stomach and its possible role. Domest Anim Endocrinol 2001;21(1):17-24.
19. Hataya Y, Akamizu T, Takaya K, Kanamoto N, Ariyasu H, Saijo M, Moriyama K, Shimatsu A, Kojima M, Kangawa K, Nakao K. A low dose of ghrelin stimulates growth hormone (GH) release synergistically with GH-releasing hormone in humans. J Clin Endocrinol Metab 2001;86(9):4552.
20. Gualillo O, Caminos J, Blanco M, Garcia-Caballero T, Kojima M, Kangawa K, Dieguez C, Casanueva F. Ghrelin, a novel placental-derived hormone. Endocrinology 2001;142(2):788-94.
21. Gualillo O, Caminos JE, Kojima M, Kangawa K, Arvat E, Ghigo E, Casanueva FF, Dieguez C. Gender and gonadal influences on ghrelin mRNA levels in rat stomach. Eur J Endocrinol 2001;144(6):687-90.
22. Date Y, Nakazato M, Murakami N, Kojima M, Kangawa K, Matsukura S. Ghrelin acts in the central nervous system to stimulate gastric acid secretion. Biochem Biophys Res Commun 2001;280(3):904-7.
23. Ariyasu H, Takaya K, Tagami T, Ogawa Y, Hosoda K, Akamizu T, Suda M, Koh T, Natsui K, Toyooka S, Shirakami G, Usui T, Shimatsu A, Doi K, Hosoda H, Kojima M, Kangawa K, Nakao K. Stomach is a major source of circulating ghrelin, and feeding state determines plasma ghrelin-like immunoreactivity levels in humans. J Clin Endocrinol Metab 2001;86(10):4753-8.
1. Takaya K, Ariyasu H, Kanamoto N, Iwakura H, Yoshimoto A, Harada M, Mori K, Komatsu Y, Usui T, Shimatsu A, Ogawa Y, Hosoda K, Akamizu T, Kojima M, Kangawa K, Nakao K. Ghrelin strongly stimulates growth hormone release in humans. J Clin Endocrinol Metab 2000;85(12):4908-11.
2. Peino R, Baldelli R, Rodriguez-Garcia J, Rodriguez-Segade S, Kojima M, Kangawa K, Arvat E, Ghigo E, Dieguez C, Casanueva FF. Ghrelin-induced growth hormone secretion in humans. Eur J Endocrinol 2000;143(6):R11-4.
3. Nakazato M, Hanada R, Murakami N, Date Y, Mondal MS, Kojima M, Yoshimatsu H, Kangawa K, Matsukura S. Central effects of neuromedin U in the regulation of energy homeostasis. Biochem Biophys Res Commun 2000;277(1):191-4.
4. Mori K, Yoshimoto A, Takaya K, Hosoda K, Ariyasu H, Yahata K, Mukoyama M, Sugawara A, Hosoda H, Kojima M, Kangawa K, Nakao K. Kidney produces a novel acylated peptide, ghrelin. FEBS Lett 2000;486(3):213-6.
5. Masuda Y, Tanaka T, Inomata N, Ohnuma N, Tanaka S, Itoh Z, Hosoda H, Kojima M, Kangawa K. Ghrelin stimulates gastric acid secretion and motility in rats. Biochem Biophys Res Commun 2000;276(3):905-8.
6. Kojima M, Haruno R, Nakazato M, Date Y, Murakami N, Hanada R, Matsuo H, Kangawa K. Purification and identification of neuromedin U as an endogenous ligand for an orphan receptor GPR66 (FM3). Biochem Biophys Res Commun 2000;276(2):435-8.
7. Hosoda H, Kojima M, Matsuo H, Kangawa K. Purification and characterization of rat des-Gln14-Ghrelin, a second endogenous ligand for the growth hormone secretagogue receptor. J Biol Chem 2000;275(29):21995-2000.
8. Hosoda H, Kojima M, Matsuo H, Kangawa K. Ghrelin and des-acyl ghrelin: two major forms of rat ghrelin peptide in gastrointestinal tissue. Biochem Biophys Res Commun 2000;279(3):909-13.
9. Date Y, Murakami N, Kojima M, Kuroiwa T, Matsukura S, Kangawa K, Nakazato M. Central effects of a novel acylated peptide, ghrelin, on growth hormone release in rats. Biochem Biophys Res Commun 2000;275(2):477-80.
10. Date Y, Kojima M, Hosoda H, Sawaguchi A, Mondal MS, Suganuma T, Matsukura S, Kangawa K, Nakazato M. Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans. Endocrinology 2000;141(11):4255-61.
1. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999;402(6762):656-60.
2. Michishita, M., Minegishi, T., Abe, K., Kangawa, K., Kojima, M. & Ibuki, Y. Expression of adrenomedullin in the endometrium of the human uterus. Obstet Gynecol 93, 66-70 (1999).
3. Minegishi, T., Nakamura, M., Abe, K., Tano, M., Andoh, A., Yoshida, M., Takagi, T., Nishikimi, T., Kojima, M. & Kangawa, K. Adrenomedullin and atrial natriuretic peptide concentrations in normal pregnancy and pre-eclampsia. Mol Hum Reprod 5, 767-70 (1999).
(1999年以前のいくつかの発表論文)
1. Mizuno, K., Kojima, M. & Matsuo, H. A putative prohormone processing protease in bovine adrenal medulla specifically cleaving in between Lys-Arg sequences. Biochem Biophys Res Commun 128, 884-91 (1985).
(最初に私の名前が載った論文。筆頭著者の水野さんはいまや東北大学教授として活躍中である。毎日、冷房室で実験していたことを思い出す。)
2. Kubo, T., Fukuda, K., Mikami, A., Maeda, A., Takahashi, H., Mishina, M., Haga, T., Haga, K., Ichiyama, A., Kangawa, K., Kojima, M., Matsuo, H., Hirose, T., Numa, S. & et al. Cloning, sequencing and expression of complementary DNA encoding the muscarinic acetylcholine receptor. Nature 323, 411-6 (1986).
3. Mizuno, K., Sakata, J., Kojima, M., Kangawa, K. & Matsuo, H. Peptide C-terminal alpha-amidating enzyme purified to homogeneity from Xenopus laevis skin. Biochem Biophys Res Commun 137, 984-91 (1986).
4. Tanabe, T., Takeshima, H., Mikami, A., Flockerzi, V., Takahashi, H., Kangawa, K., Kojima, M., Matsuo, H., Hirose, T. & Numa, S. Primary structure of the receptor for calcium channel blockers from skeletal muscle. Nature 328, 313-8 (1987).
5. Kojima, M., Minamino, N., Kangawa, K. & Matsuo, H. Cloning and sequence analysis of cDNA encoding a precursor for rat brain natriuretic peptide. Biochem Biophys Res Commun 159, 1420-6 (1989).
6. Kojima, M., Mizuno, K., Kangawa, K. & Matsuo, H. Purification and characterization of a peptide C-terminal alpha-amidating enzyme from porcine atrium. J Biochem (Tokyo) 105, 440-3 (1989).
(大学院時代の研究をまとめた私の最初の論文。思い返してみると、実験データが少なく恥ずかしい内容なので、発表後、一度も読み返したことがない。そういえば、これ以外の論文も発表後はほとんど読み返したことがない。グレリンの論文でも、後にチラッと図をみただけ。なぜか、過去の論文は恥ずかしい!)
7. Kojima, M., Minamino, N., Kangawa, K. & Matsuo, H. Cloning and sequence analysis of a cDNA encoding a precursor for rat C-type natriuretic peptide (CNP). FEBS Lett 276, 209-13
8. Kitamura, K., Sakata, J., Kangawa, K., Kojima, M., Matsuo, H. & Eto, T. Cloning and characterization of cDNA encoding a precursor for human adrenomedullin. Biochem Biophys Res Commun 194, 720-5 (1993).
9. Kojima, M., Ohyama, Y., Miyamoto, K., Minamino, N., Kangawa, K. & Matsuo, H. Cloning and characterization of a novel natriuretic peptide in frog (Rana catesbeiana). J Biol Chem 269, 13136-40 (1994).
10. Kojima, M., Hisaki, K., Matsuo, H. & Kangawa, K. A new type soluble guanylyl cyclase, which contains a kinase-like domain: its structure and expression. Biochem Biophys Res Commun 217, 993-1000 (1995).